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Type Journal Article - European Respiratory Journal
Title Lung function differences between subjects with tobacco smoke-induced COPD (TS-COPD) and biomass smoke-induced COPD (BS-COPD) in an Indian population
Author(s)
Volume 38
Issue Suppl 55
Publication (Day/Month/Year) 2011
Page numbers 0-0
URL https://erj.ersjournals.com/content/38/Suppl_55/p918.short
Abstract
Abstract
Exposure to biomass fuel smoke is as an important risk factor for COPD (BS-COPD), but it is not known whether this phenotype is different from tobacco-smoke-induced COPD (TS-COPD) with reference to lung physiological changes.

Aim: To compare lung function profiles between subjects with BS-COPD and TS-COPD.

Methods: 17 BS-COPD (mean 43 yrs exposure) and 35 TS-COPD (mean 43 smoking pack yrs) subjects underwent pre and post bronchodilator spirometry to measure FEV1, FVC and FEF25-75%, body plethysmography to measure residual volume (RV) and total lung capacity (TLC), impulse oscillometry (IOS) to measure R5Hz and R20Hz and single-breath DLCO to measure lung diffusion. Two sample “t” test was used to compare mean (±SD) lung function parameters between the two groups.

Results: There were no significant differences in% predicted values for FEV1, FVC, R20Hz, RV and TLC between TS-COPD and BS-COPD (all p values >0.05). However, BS-COPD showed a trend towards greater small airway obstruction indicated by lower FEF25-75% predicted values [BS: 9% (±3%) vs TS: 12% (±5%), p= 0.02], higher R5Hz% predicted values [BS: 272% (±65%) vs TS: 222% (±94%), p= 0.05] and higher R5-20Hz values normalised to total airway resistance [BS: 0.53 (±0.07) vs TS: 0.46 (±0.13) p=0.05], while TS-COPD showed lower% predicted values for DLCO [TS: 53% (±24%) vs BS: 71% (±33%); p=0.03].

Conclusion: BS-COPD shows similar decrements in Spirometric, IOS and body plethysmographic parameters as TS-COPD. However, BS-COPD was associated with greater small airways obstruction, while TS-COPD was associated with lower DLCO values.
Bill Brashier, Nitin Vanjare , Vandana Vincent , Jyoti Londhe , Sapna Madas , Sanjay Juvekar , Peter Barnes , and Sundeep Salvi. "Lung function differences between subjects with tobacco smoke-induced COPD (TS-COPD) and biomass smoke-induced COPD (BS-COPD) in an Indian population." European Respiratory Journal 38, no. Suppl 55 (2011): 0-0.
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