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Citation_information

Type Journal Article - BMC Nutrition
Title Efficacy of transdermal delivery of liposomal micronutrients through body oil massage on neurodevelopmental and micronutrient deficiency status in infants: results of a randomized placebo-controlled clinical trial
Author(s)
Publication (Day/Month/Year) 2021
URL https://bmcnutr.biomedcentral.com/articles/10.1186/s40795-021-00458-8
Abstract
Background: Micronutrient deficiency is a known cause of adverse neurodevelopment and growth. Poor
adherence to oral regimes of micronutrient supplements is a known challenge during the implementation of
supplementation programs. The present study evaluates the benefits of liposomal encapsulated micronutrient
fortified body oils (LMF oil) that can be used for infant body massage in terms of neurodevelopment and
prevention of deficiency.
Study design: Double-blind randomized clinical trial.
Methods: A total of 444 healthy infants aged 4-7 weeks were randomized to receive either LMF oil (containing iron,
vitamin D, folate, and vitamin B12) or placebo oil for gentle body massage till 12 months of age. Blood samples
were collected at 6 and 12 months for transferrin saturation (TSAT), hemoglobin, and 25-hydroxy vitamin (25-OH-D)
levels. Mental and motor development was assessed at 12 months using developmental assessment for Indian
Infants (DASII).
Results: A total of 391 infants completed the study. There was no significant improvement in the hemoglobin in
the intervention group at 12 months of age as compared to the placebo group [− 0.50 vs.-0.54 g%]. There was a
marginally significant improvement in 25-OH-D at 12 months in the LMF oil group [+ 1.46vs.-0.18 ng/ml, p = 0.049].
In the subgroup of infants with moderate anemia, the intervention prevented the decline in hemoglobin at 12
months of age [adjusted mean change + 0.11vs.-0.51 g%, p = 0.043]. The mental or motor developmental quotients
in the intervention group were not significantly different from those in the placebo group.
Aditi Apte, Mudra Kapoor , Sadanand Naik , Himangi Lubree , Pooja Khamkar , Diksha Singh , Dhiraj Agarwal , Sudipto Roy , Anand Kawade , Sanjay Juvekar , Rinti Banerjee , and Ashish Bavdekar. "Efficacy of transdermal delivery of liposomal micronutrients through body oil massage on neurodevelopmental and micronutrient deficiency status in infants: results of a randomized placebo-controlled clinical trial." BMC Nutrition (2021).
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