Central Data Catalog


Type Journal Article - PLoS neglected tropical diseases
Title Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol
Volume 12
Issue 1
Publication (Day/Month/Year) 2018
Page numbers e0005988-0
URL https://doi.org/10.1371/journal.pntd.0005988
Hybrid trials that include both clinical and implementation science outcomes are increasingly relevant for public health researchers that aim to rapidly translate study findings into evidence-based practice. The DeWorm3 Project is a series of hybrid trials testing the feasibility of interrupting the transmission of soil transmitted helminths (STH), while conducting implementation science research that contextualizes clinical research findings and provides guidance on opportunities to optimize delivery of STH interventions. The purpose of DeWorm3 implementation science studies is to ensure rapid and efficient translation of evidence into practice. DeWorm3 will use stakeholder mapping to identify individuals who influence or are influenced by school-based or community-wide mass drug administration (MDA) for STH and to evaluate network dynamics that may affect study outcomes and future policy development. Individual interviews and focus groups will generate the qualitative data needed to identify factors that shape, contextualize, and explain DeWorm3 trial outputs and outcomes. Structural readiness surveys will be used to evaluate the factors that drive health system readiness to implement novel interventions, such as community-wide MDA for STH, in order to target change management activities and identify opportunities for sustaining or scaling the intervention. Process mapping will be used to understand what aspects of the intervention are adaptable across heterogeneous implementation settings and to identify contextually-relevant modifiable bottlenecks that may be addressed to improve the intervention delivery process and to achieve intervention outputs. Lastly, intervention costs and incremental cost-effectiveness will be evaluated to compare the efficiency of community-wide MDA to standard-of-care targeted MDA both over the duration of the trial and over a longer elimination time horizon.
Arianna Rubin Means, Sitara SR Ajjampur , Robin Bailey , Katya Galactionova , Marie-Claire Gwayi-Chore, , Katherine Halliday , Moudachirou Ibikounle, , Sanjay Juvekar , Khumbo Kalua , Gagandeep Kang , Pallavi Lele , Adrian JF Luty , Rachel Pullan , Rajiv Sarkar , Fabian Schär , Fabrizio Tediosi , Bryan J Weiner , Elodie Yard , Judd Walson , and DeWorm3 Implementation Science Team. "Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol." PLoS neglected tropical diseases 12, no. 1 (2018): e0005988-0.
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