Central Data Catalog


Type Journal Article - Vaccine
Title Assessment of risk of intussusception after pilot rollout of rotavirus vaccine in the Indian public health system
Volume 38
Issue 33
Publication (Day/Month/Year) 2020
Page numbers 5241-5248
URL https://doi.org/10.1016/j.vaccine.2020.05.093
Pre-licensure trials of ROTAVAC® were not adequately powered to assess risk of intussusception, a rare adverse event associated with other rotavirus vaccines in some settings. We examined the risk of intussusception after ROTAVAC® vaccination among Indian infants during pilot rollout of the vaccine in the public health system in three states - Himachal Pradesh, Maharashtra and Tamil Nadu.

Passive surveillance for intussusception was set up in 35 sentinel health facilities covering 26.3 million population in the three states under monitoring of an Interministerial-Interagency Steering Committee. Clinical and immunization data were collected by independent teams. An expert committee blinded to vaccination status, classified intussusception cases using Brighton criteria. The self-controlled case-series method was used to estimate risk of intussusception (Brighton Level 1) after ROTAVAC® vaccination.

151 intussusception cases were included in the analysis. The relative incidence (incidence during the risk period compared to the control period) 1–21 days after doses 1 and 2 combined was 1.56 (95% CI, 0.0–5.28) and that for three doses combined was 1.88 (95% CI, 0.76–4.30). Attributable risk 1–21 days after doses 1 and 2 combined was 0.11 (95% CI, 0.0–0.25) and that for 3 doses combined was 0.42 (95% CI, 0.0–0.70) per 100,000 doses.

No increased risk of intussusception within 21 days of receipt of the first two doses combined or all 3 doses combined of ROTAVAC® was detected.
Nita Bhandari, Kalpana Antony , Vinohar Balraj , Temsunaro Rongsen-Chandola , Tivendra Kumar , Bireshwar Sinha , Nidhi Goyal , Rajesh Guleri , Ashish Bavdekar , Sanjay Juvekar , Girish Dayma , Vaijayanti Patwardhan , Archana Patil , Gagandeep Kang , Venkata Raghava Mohan , Rajan Srinivasan , Sridevi A Naaraayan , Samarasimha Reddy , Maharaj Kishan Bhan , Tataji Surender Rao , Umesh Parashar , Jaya Prakash Muliyil , Jaqueline Tate , Nicholas J Andrews , Prasanna Samuel , Santhosh Kumar Ganesan , Sunita Taneja , Tarun Shankar Choudhary , Veereshwar Bhatnagar , Arun Kumar Gupta , and Madhulika Kabra. "Assessment of risk of intussusception after pilot rollout of rotavirus vaccine in the Indian public health system." Vaccine 38, no. 33 (2020): 5241-5248.
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